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KMID : 1037120200380010009
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The World Journal of Men′s Health
2020 Volume.38 No. 1 p.9 ~ p.23
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Microtubular Dysfunction and Male Infertility
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Gunes Sezgin
Sengupta Pallav
Henkel Ralf
Alguraigari Aabed
Sinigaglia Mariana Marques
Kayal Malik
Joumah Ahmad
Agarwal Ashok
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Abstract
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Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review (a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction.
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KEYWORD
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Axoneme, Infertility, male, Kartagener syndrome, Microtubule-associated proteins
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